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The impairment of HMGB1 perform contributes to enhanced mitochondrial DNA injury. While in the SCA1 mouse design, in excess of-expression of your HMGB1 protein by means of an introduced virus vector bearing the HMGB1 gene facilitates fix of the mitochondrial DNA harm, ameliorates the neuropathology and the motor deficits, and https://bobq432fhi3.wikilentillas.com/user

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