At three times put up-MPTP, we located substantial microglial activation and up-regulation of CB2 cannabinoid receptors while in the ventral midbrain. Remedy with Earn or perhaps the CB2 receptor agonist JWH015 (four mg/kg, intraperitoneal) diminished MPTP-induced microglial activation, whereas genetic ablation of CB2 receptors exacerbated MPTP systemic toxicity. On top https://win55.clinic/tin-tuc